As a common antiemetic premedication, palonosetron 0. The dose should be rounded to nearest 50mg and swallowed whole on an empty stomach or an hour before food. Modified oneday etoposide and cisplatin combination for previously. May 11, 2016 cisplatin and etoposide plus radiation followed by nivolumabplacebo for locally advanced nsclc the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Hi therei was diagnosed with terminal stage 111 lung cancer lymphnodes involved on april 14th 2008. During chemotherapy plus radiation therapy, cisplatinetoposide therapy is preferred. The usual intravenous dose of etoposide ranges from 50120 mgm 2 daily for 5 days. Etoposide and cisplatin chemotherapy, known as ep or sometimes pe, is used. However, chemotherapy agents are subject to the rules of pharmacokinetics and thus have the potential for drug interactions.
It is best to read this information with our general information about chemotherapy and the type of cancer you have. In both arms, treatment repeats every 3 weeks for up to 3 courses in the absence of disease progression or unacceptable toxicity. The usual oral dose of etoposide is 100240 mgm 2 daily for 5 consecutive days. Weekly alternating therapy with irinotecan plus cisplatin and. Comparison of amrubicin and weekly cisplatinetoposide. Dec 01, 2007 my dad is currently on his second round of cisplatin and etoposide. It felt good, better than letting it fall out bit by bit. Consider growth factor support if patients have needed deferrals due to neutropenia or treatment for neutropenic infection.
Small cell lung cancer treatment regimens part 2 of 3 subsequent systemic therapy 1 continued relapse. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Modified oneday etoposide and cisplatin combination for. Two hundred eightytwo of 289 patients 98% achieved a complete response. Despite the fair sensitivity of sclc to chemotherapy. Cisplatin dose 2 50mgm etoposide 100mgm2 iv infusion ml 0. These drugs travel through the bloodstream and reach most parts of the body. Appendices a through g provide supplementary information about common topics across the library of chemotherapy order templates. Etoposide and cisplatin chemotherapy for metastatic goodrisk.
Bleomycin, etoposide, and cisplatin in treating patients with. Below is an example of an nccn chemotherapy order template, crv1. Etoposide, cisplatin, and bleomycin were considered by a previous iarc working group in 1999 iarc, 2000. Side effects,cisplatin,etoposide and radiation cancer. For example, patients receiving doses of 35 mgm2 have. Ep is usually given into a vein and also as capsules.
Facilities to treat anaphylaxis must be present when the chemotherapy is administered. Cisplatin 1mgml concentrate for solution for infusion. Three hours after a bolus injection and two hours after the end of a threehour infusion, 90% of the plasma platinum is protein bound. Well, i originally had cisplatin and etoposide, and about two weeks into treatment i discovered clumps of hair were coming out when i combed. Mathematical optimisation of the cisplatin plus etoposide. In the event that the patient cannot swallow capsules, etoposide injection can be taken orally diluted with. My dad is currently on his second round of cisplatin and etoposide. His schedule is 68 hours of cisplatin on monday and 2 hours of etoposide on tuesday friday. I got out a razor and sat in the bathroom for an hour shaving let me tell you, its hard to shave the back of your own head. Bleomycin, etoposide, and cisplatin in treating patients. Ep consisted of four cycles of etoposide 100 mgm2 and cisplatin 20 mgm2 on days 1 to 5 every 21 days. Chemotherapy chemo is treatment with anticancer drugs that may be injected into a vein or taken by mouth. Bc cancer protocol summary for treatment of extensive stage.
This is the basis for combining chemotherapy agents with different mechanisms of action. This randomized phase ii trial studies how well temozolomide and capecitabine work compared to standard treatment with cisplatin and etoposide in treating patients with neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other parts of the body metastatic or cannot be removed by surgery. Treatment with etoposide and cisplatin is administered on 5 consecutive days days 15, of a 21 day cycle and repeated for 4 cycles or until disease progression or unacceptable toxicity develops. Alternatively, 100 mgm 2 has been given on alternate days to a total of 300 mgm 2. Small cell lung cancer sclc represents % of total lung cancer cases in the united states, with the number of cases for 2008 estimated at 28,000. Jul 17, 2019 anaphylacticlike reactions to cisplatin such as facial edema, bronchoconstriction, tachycardia, and hypotension have been reported and may occur within minutes of cisplatin administration. Combination cisplatinbased chemotherapy generally consists of bleomycin and etoposide plus cisplatin bep or etoposide plus cisplatin ep. Based on this information, our own institutional guidelines for drug sequencing. Chemo advice please re cisplatin and etoposide cancer chat. Dec 20, 2005 ep consisted of four cycles of etoposide 100 mgm2 and cisplatin 20 mgm2 on days 1 to 5 every 21 days. Cisplatin dosing, indications, interactions, adverse. Small cell lung cancer treatment regimens part 1 of 3. Weekly alternating therapy with irinotecan plus cisplatin. Etoposide 50mgm iv with concurrent thoracic radiotherapy.
He has done very well with the nausea, in fact, he only had one day where he was sick. Etoposide phosphate is administered by intravenous infusion. He does this for 6 days, and then he is off for 4 weeks. Short hydration in chemotherapy containing cisplatin. Etoposide and cisplatin chemotherapy for metastatic good. In an effort to improve response rates to chemotherapy, agents often are combined to give a socalled twoprong attack against tumor cells. Cisplatin plus etoposide combination is the standard firstline treatment of poorly differentiated nets, independent of the primary tumor site and whether it is a surgically excised grade 3 gepnet.
I had the same chemo your husband is having and i did radiation on the same days as chemo. Patients receive etoposide and cisplatin as in arm i. Chemo is typically part of the treatment for small cell lung cancer sclc. Smallcell lung cancer sclc is a distinct entity that accounts for 15%. Bleomycin, etoposide, and cisplatin in treating patients with metastatic germ cell cancer of the testicles. Smallcell lung cancer sclc represents one of the most aggressive forms of lung cancer. Cisplatin dosing, indications, interactions, adverse effects. Cisplatin and etoposide plus radiation followed by. Pdf a randomized trial of cisplatin, etoposide and. Etoposide and cisplatin versus irinotecan and cisplatin in patients with limitedstage smallcell lung cancer treated with etoposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy jcog0202. Nccn chemotherapy order templates nccn templates are intended for personal and practical use only. Cisplatin hydration for outpatients chemotherapy regimen. Chemotherapy for small cell lung cancer lung cancer chemo. In 100 people receiving cisplatin, etoposide, more than 20 and up to 100 may have.
As we strive to keep these documents uptodate, revisions are frequent and ongoing, we ask that you always obtain a new form from this listing each time you prescribe these drugs. Template header regimen name the template header lists the cancer type for which the regimen is recommended, and is associated with a specific nccn guideline. Also consider if deemed particularly high risk for life threatening sepsis. Etoposide and cisplatin, known as ep or sometimes pe, is a combination chemotherapy treatment used to treat different cancers. Possible side effects of cisplatin, etoposide table version date. Chemo orders and consents penn state cancer institute. The information contained in the nccn templates is based on the nccn clinical practice guidelines in oncology. Patients also receive bleomycin iv continuously over 72 hours on days. Infection, especially when white blood cell count is low. Cisplatin and etoposide plus radiation followed by nivolumab.
Cisplatin oral etoposide rotterdam regimen cisplatin andetoposide rotterdamprotocolcrp09gy005 v1 4 page 3 of 4 issue date 04092018 expiry date. Cisplatin is used to treat various types of cancer. Fatigue was at top of list, nausea, lost weight, hair, bowel irregularities, some joint pain, had 5 blood transfusions both red and platelets. Chemo orders and consents the list of disease and specialty groups below are links to available chemotherapy orders and consents frequently used in their treatment. It is an aggrssive treatment but as you can seei am still herefeb. Chemo advice please re cisplatin and etoposide 16 oct 2012 21. I had 20 treatments of cisplatin over a 10 week period 57 days and after each rd 5 days a week every 2 weeks it beocme more intense. Since that time, new data have become available, these have been incorporated into the monograph, and taken into consideration in the present evaluation.
None of the regimens showed a difference in efficacy based on chemotherapy administration sequencing. The mean relative dose intensity of etoposide and cisplatin was. The nccn recommends cancer patient participation in clinical trials as the gold standard for treatment. Cisplatin and etoposide plus radiation followed by nivolumabplacebo for locally advanced nsclc the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. A randomized trial of cisplatin, etoposide and bleomycin peb versus carboplatin, etoposide and bleomycin ceb for patients with goodrisk metastatic nonseminomatous germ cell tumors. This is because sclc has usually already spread by the time it is found, so other. Treatment with cisplatin and etoposide in patients with. Lung cancer is the most common cause of cancer death worldwide. May 11, 2006 arm ii longinfusion schedule of bleomycin. May use concomitant amifostine to decrease nephrotoxicity. Instructions on how you can make a pdf version of this page using the print.
Cisplatin dose etoposide then this would be used as prehydration i. Small cell lung cancer sclc with cisplatin and etoposide. Etoposide and cisplatin chemotherapy ep macmillan cancer. Patients received cisplatinbased chemotherapy with a cisplatin dose of. On occasion, it may be given in the hospital if someone is too sick. Endorsed resources are listed that may be helpful in applying the information contained in the chemotherapy order templates. Bcca protocol summary for adjuvant cisplatin and etoposide following resection of.
Iv infusion 2 and 3 2etoposide 200mgm po cycle frequency 21 days number of cycles 4 6 cycles usually 4 administration cisplatin is administered in 500ml sodium chloride 0. Both etoposide and cisplatin are given on day 1, followed by etoposide alone on day 2 and 3 of a 21 day cycle. Care plan template page 4 of 6 27032015 growth factor support for patients on sequential chemoradiotherapy. Nccn continues to add to the library of chemotherapy order templates to improve the safe use of drugs and biologics in cancer care. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should. Jan 26, 2020 dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position. Exercise caution to prevent inadvertent cisplatin overdose as doses greater than 100 mgm2cycle once every 3 to 4 weeks are rarely used. Each section is described in more detail using the associated letters. Repeat cycle every 2 weeks until disease progression or unacceptable toxicity. The complexes between albumin and the platinum from cisplatin do not dissociate to a. Summary of product characteristics accessed july 2017. Fiveday oral etoposide treatment for advanced smallcell lung.
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