Food interactions with sustainedrelease theophylline. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in nature, being present in tea camellia. All interactions with theophylline slophyllin, theodur coadministered drug dose of drug dose of theophylline effect on drug levels effect on theophylline levels potential clinical effects mechanism of interaction management. Dailymed theophylline theophylline anhydrous solution. Theophylline remains one of the most widely prescribed drugs for the treatment of asthma and chronic obstructive pulmonary disease copd worldwide, since it is inexpensive and widely available. We would like to show you a description here but the site wont allow us. Drug interactions are reported among people who take levofloxacin and theophylline together.
Pharmacokinetic drug interactions of antimicrobial drugs mdpi. Avoid excessive intake of coffee, tea, cocoa, cola beverages, and chocolate. Interaction between theophylline and tacrolimus in a renal transplant patient article pdf available in nephrology dialysis transplantation 157. Increases in theophylline bioavailability following lansoprazole. Therefore, the drug should only be used with caution in patients with a history of peptic ulcer disease. Before addition of a newly available drug in a patient receiving theophylline, the package insert of the new drug andor the medical literature should be consulted to determine if an interaction between the new drug and theophylline has been reported. Clinically significant drug interactions with theophylline. Pharmacokinetic drug interaction profiles of proton pump inhibitors. Theophylline remains one of the most widely prescribed drugs for the. Although clinically often unrecognized, many of the drug interactions are responsible for.
Theophylline drug interactions among the drugs that can potentially interact with theophylline are alcohol, cimetidine, and certain antibiotics. Smoking cigarettes or other tobacco products may markedly influence the effects of theophylline. Interaction between phenytoin and theophylline in healthy volunteers. Theophylline is a drug that has been in use for asthma since the 1950s.
Review article pharmacogenomics and herbdrug interactions. The plasmatheophylline concentration is increased in heart failure, hepatic impairment, and in viral infections. Aerolate 111 oral, aerolate iii td oral, aerolate jr oral, aerolate sr oral, aquaphyllin oral, asmalix oral, bronkodyl oral, bronkodyl sr oral, constantt oral, elixophyllin oral, elixophyllin sr oral, liquophylline oral, lixolin oral, lodrane oral, lodrane260 oral, norophylline oral, quibront oral, quibrontsr oral, respbid oral, slobid 100 oral, slobid 300 oral, slobid 50 oral, slo. Theophylline new perspectives for an old drug american journal. Theophylline toxicity, mainly iatrogenic, can cause seizures in patients without known underlying epilepsy. Aquaphyllin, asmalix, elixophyllin theophylline uses. Drug interactions are an important consideration in. If patient is already taking theophylline, give smaller loading dose. Johns wort can affect your blood levels of theophylline.
These medications may interact and cause very harmful effects. When theophylline is given with enteral tube feedings, blood levels may be decreased due to interference with its absorption. Theophylline drug interactions can alter the level of theophylline in your blood or make some drugs less effective, among other things. Approximately 50% of the treated subjects experience sideeffects. My next question is regarding theophylline, in the example given the patient suffered from copd and was taking a course of erythromycin, both of which reduce clearance by 20% eachupon working out the. The influence of the type and amount of other foods, as well as the time interval between drug and food, has not been studied. Cytochrome p450 cyp 1a2 drugdrug interaction ddi network. Differences in the halflife of theophylline are important because. Interaction between phenytoin and theophylline in healthy. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be. Theophylline oral interactions with other medication.
Drug interactions may change how your medications work or increase your risk for serious side effects. Individual patients may experience larger changes in serum theophylline concentrations than the value listed. Other medications can affect the removal of theophylline from your body, which may affect how theophylline works. Following summary of reports on theophylline shows theophylline is an effective drug with bronchodilating and. Theophylline interactions bnf content published by nice. See what others have said about theophylline, including the effectiveness, ease of use and side effects. This study is created by ehealthme based on reports of 26 people who take theophylline and alcohol from food and drug administration fda, and is updated regularly. Side effects are related to plasma concentrations and include nausea, vomiting.
It is preferable not to smoke while you are taking this drug. Theophylline comes as an extendedrelease longacting tablet, extendedrelease capsule, and a solution liquid to take by mouth. For more information on the process used to assess the herbdrug interaction research and why some research is not included. The kinetics of iv aminophylline or oral theophylline were not altered in healthy volunteers after, respectively, a 3 or 5 day treatment with azithromycin 250 mg day. Blocks adenosine receptors, often necessitating a higher dose of adenosine to achieve the desired effect. We look into the drug interactions by gender and age. Its also available in an intravenous iv form, which is. Theophylline fda prescribing information, side effects.
Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e. Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see commonlyused drugs that interact with theophylline. Hello, ive got a pharmacy practise exam coming up soon and part of it is tdm of digoxin and theophylline. Dailymed theophylline anhydrous theophylline tablet. This includes prescription and overthecounter medicines, vitamins, and herbal products. Theophylline tends to be more potent and longer acting than aminophylline. The frequency of side effects and the relatively low efficacy of. The clearance of theophylline is affected by many variables which necessitate carefully individualized dosage. Theophylline is proposed to be retained in the who model list of essential medicines for 25. Calculate initial dosage using the following equation. Johns wort can decrease the level of theophylline in your blood, perhaps making it less effective. Theo 24, theocron theophylline dosing, indications. This study is created by ehealthme based on reports of 186 people who take levofloxacin and theophylline from the food and drug administration fda, and is updated regularly. Drug interactions are reported among people who take theophylline and alcohol together.
Theophylline is a widely used bronchodilator and a very potent central nervous system cns stimulant. Taking theophylline extendedrelease tablets immediately after ingesting a high fat content meal 45 g fat, 55 g carbohydrates, 28 g protein, 789 calories may result in a somewhat higher c max and delayed t max and a somewhat greater extent of absorption when compared to taking it in the fasting state. The clinician should not assume that a drug does not interact with theophylline if it is not listed here. Similar to drug drug interactions, the multicomponent herbs can exert their effects on pharmacokinetics and consequently lead to herb drug interactions hdis. Tell your doctor about all your current medicines and any medicine you start or stop using. To minimize potential for interaction, you may interrupt the feeding for one hour before and one hour after the theophylline dose. This may reduce the effectiveness of the medication. This document does not contain all possible drug interactions. Medicines action on the respiratory tract antiasthmatic and medicines for chronic obstructive pulmonary disease. At serum theophylline concentrations 20 mcgml, both the frequency and severity of adverse reactions increase. Therefore, combining betaadrenergic bronchodilators with loop diuretics, for.
Theophylline uniphyl and theo24 side effects, dosage. Theophylline elixophyllin, theo24 is a bronchodilator prescribed for the treatment of asthma and other airway conditions. During treatment with theophylline, do not start or stop taking st. On the other hand, association of theophylline with ciprofloxacin, for instance. Since up to 90% of a theophylline dose is biotransformed, drugs influencing microsomal enzyme systems in the liver may affect the elimination of theophylline. Theophylline is a methylxanthine derived from the group called xanthines. Pdf interaction between theophylline and tacrolimus in a. Whatever the mechanism, the interaction may be sufficient to necessitate adjustment of the theophylline dosage.
Pdf theophylline 3methyxanthine has been used to treat airway. Merge of future and tradition mouzeliu, 1,2 yuelizhang, 1,2 meizizeng, 1,2 fazhonghe, 1,2 zhiyingluo, 1,2 jianquanluo, 1,2 jiagenwen, 1,2 xiaopingchen, 1,2 honghaozhou, 1,2 andweizhang 1,2 department of clinical pharmacology, xiangya hospital, central south university, changsha, china. Currently, theophylline is being used predominantly as sustainedrelease capsules or tablets. Pharmacokinetic drug interactions with theophylline. Many drugs interact with theophylline by inhibiting or potentiating its metabolism by cyp1a2 see. Theophylline, also known as 1,3dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease copd and asthma under a variety of brand names.
Review article pharmacogenomics and herb drug interactions. Its available as an oral solution, an extendedrelease tablet, and an extendedrelease capsule. These contain theophyllinerelated substances that may increase your side effects. Since 1983, theophylline preparations that can be given with an interval of 24 hours oncedaily preparations have become available. Age, smoking, congestive heart failure, other diseases and drug interactions all contribute to a change in the metabolism of theophylline. Additional articles were also obtained from manual searches of the reference lists of relevant.
Combining clr with theophylline in a latinsquare design study of 8 patients did not result in any significant pk changes 216. Similar to drugdrug interactions, the multicomponent herbs can exert their effects on pharmacokinetics and consequently lead to herbdrug interactions hdis. Side effects are related to plasma concentrations and include nausea. In many industrialized countries, however, theophylline has become a thirdline treatment that is only used in poorly. Theophylline is the generic name for the prescription drugs uniphyl in canada and theo24. The plasmatheophylline concentration is decreased in smokers, and by alcohol consumption. Theophylline and alcohol drug interactions a study of fda. The drugs theophylline and aminophylline are often spoken of together, though aminophylline is a derivative of theophylline, and differs somewhat in its structure from theophylline. The most common types of seizures are generalized and partial seizures with secondary generalization,151,152 but status epilepticus can occur in approximately 30% of. Fluvoxamine and theophylline pbpk model building was started with.
If you are taking these drugs together, your healthcare provider may need to adjust your theophylline dosage. Only a few drug interactions involving ppis are of clinical significance. There were no significant metabolic interactions when combining. Its used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest. In the midseventies the first preparations for use with a dosage interval of 12 hours twicedaily preparations were introduced. Understanding the exact mechanism of each extract of an herb that affects drugs absorption, distribution, metabolism, and excretion adme properties is incomplete at the moment. Structurally related to caffeine, it was first isolated from tea leaves in the late. In general, maintaining the average serum theophylline concentration between 10 and 15 mcgml will achieve most of the drugs potential therapeutic benefit while minimizing the risk of serious adverse events. Macrolide induced clinically relevant drug interactions with. Common side effects include cough, headaches, vomiting, nausea, and diarrhea. To reduce the risk of developing potentially dangerous drug interactions with theophylline, you should talk with your healthcare provider or pharmacist about any theophylline interactions that may apply to you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Longacting betaadrenergic bronchodilators, tiotropium, and theophylline are. The effect of phenytoin, 100 mg thrice daily for 3 weeks, on theophylline disposition was studied in eight healthy volunteers.
Theophylline interacts with a wide variety of drugs. Theophylline is known to stimulate gastric acid secretion and may also act as a local g. Theophylline levels above 35 mgl increase the incidence of seizures and cardiac arrythmias. Johns wort without first talking with your healthcare provider. The drug is metabolised in the liver by cytochrome p450 isoenzymes, principally cyp1a2, to demethylated and hydroxylated products. Theophylline may cause arrhythmia andor worsen preexisting arrhythmia.
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